Bluestem Oral Care spray (with coactiv+) is scientifically-formulated to freshen breath, help fight plaque and tartar, and promote good oral hygiene. Clinically proven safe and effective for daily use in dogs. The no-startle nozzle is easy-to-use and allows you to treat even the most sensitive of pets. Gently lift the upper lip to expose teeth and gums. Spray liberally on each side of the mouth, coating teeth and gums well. Apply once or twice daily.